SOME ANALYSES OF SAMPLES OF BENCE-JONES PROTEIN
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چکیده
منابع مشابه
Some Analyses of Samples of Bence-jones Protein
The appearance of a peculiar protein in the urine of a person suffering from multiple myeloma was discovered by Bence-Jones in 1847. Since that time proteins having similar characteristics have often been recognized in urine and have been called BenceJones protein. Although hundreds of cases have been reported, very few detailed chemical or immunological studies have been made (1) to determine ...
متن کاملSome Observations on the Nature of the ;Bence-Jones' Protein.
The peculiar protein found in the urine in cases of multiple myeloma has, since the time when Bence-Jones first described it,' been found on but few occasions, owing to the rarity of the disease with which it is associated. Notwithstanding this, a great deal of work has been done towards elucidating its characters. The result has been that the various workers have placed it in different classes...
متن کاملThe Fate of Injected Bence Jones Protein
Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only...
متن کاملWhat's in a name? Bence Jones protein
Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...
متن کاملBence Jones protein in primary systemic amyloidosis.
The recent population-based study by Kyle et al,’ which was the first to provide precise epidemiologic information about primary systemic amyloidosis, reported the demonstration of a monoclonal (M)protein in the serum or urine from 16 of 21 patients (76%) with amyloid of unequivocal Ig origin (AL). However, the number of patients in whom free monoclonal Ig light chain (ie, Bence Jones [BJ] prot...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1935
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)75205-8